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c/coldchain·posted 2 years ago by u/kian_ekstrom

week 96 check-in — 37kg down, constipation manageable, one thing confusing me

Question Cold Box ×2 The Quiet One ×3

Something I noticed reading old threads that I have not seen said out loud.

The advice on data logger in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

1,361 up / 456 down75% upvoted37 commentsid v46svx11 Apr 2024

37 comments

23 in this archive, depth 4

best — the order this archive was captured in

u/nikhil_asante58 points·2 years ago

Reconstituted or dry powder?

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u/solene_abubakar48 points·2 years ago

Reconstituted or dry powder?

Yes, exactly this, and it is the bit that took me 92 weeks to accept.

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[removed]42 points·2 years ago

[removed by moderator]

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u/kian_ekstromOP38 points·2 years ago·edited

Reconstituted or dry powder?

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/kian_ekstromOP15 points·2 years ago

Denmark to Denmark takes 16 days on average, variance is 34 days

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u/emil_marchand32 points·2 years ago

data logger is the standard, gut feeling is not

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u/cesar_teixeira-16 points·2 years ago

This is correct. Dry powder is way more robust than liquid.

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u/kian_ekstrom28 points·2 years ago
n=1 but same
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u/kian_ekstromOP18 points·2 years ago

The gel pack lasted 13 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.

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u/coldchain_karencold chain7 points·2 years ago

The gel pack lasted 13 hours in a courier van, then liquid.

Disagree on that part. 95.1% and 97.6% on the same vial is normal.

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u/anjali_tamm3 points·2 years ago

Strongly agree. Peak temperature is not the whole story.

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u/jarno_karlsen13 points·2 years ago

lyophilised powder is far more forgiving than reconstituted solution

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u/vito_chowdhury18 points·2 years ago

Yeah, data logger is the only acceptable proof.

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u/split_dose_sceptic8 points·2 years ago

Half-life is about 168 hours, so steady state lands around week 18–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/hplc_hobbyistruns their own column2 points·2 years ago

France to France takes 13 days on average, variance is 24 days

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u/iman_castellanos12 points·2 years ago

I am going to push back on this slightly.

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u/prior_auth_painappeals14 points·2 years ago

data logger is the standard, gut feeling is not

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u/honest_syringe333 points·2 years ago

Customs clearance took 7 days. Package sat unrefrigerated during that. Powder tested clean after, reconstituted solution probably would not have.

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u/nikhil_asante2 points·2 years ago

Customs clearance took 7 days.

Adding to this: cold chain is doing more work than the comment implies.

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u/cesar_teixeira11 points·2 years ago·edited

This is correct. Dry powder is way more robust than liquid.

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u/emeka_beaulieu8 points·2 years ago

Disagree. What you are describing is consistent with ice pack, not with what you concluded.

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u/transit_variance4 points·2 years ago

Reconstituted or dry powder?

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u/nightowl_injector5 points·2 years ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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