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c/coldchain·posted 2 months ago by u/tomas_lokken

my A1c moved and I cannot work out whether packaging is why

Discussion The Quiet One ×7 Slow Clap ×3

Been lurking in c/coa for about 4 months and finally have something worth posting.

Short version: week 76, 0.25mg, and excursion is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 3 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 70.

1,723 up / 162 down91% upvoted66 commentsid 1thtkp6 May 2026

66 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/sequence_checkerresearch peptides-22 points·2 months ago
IANAD and neither is anyone upvoting this
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u/ice_pack_auditcold chain1 point·2 months ago·edited

customs clearance often breaks the cold chain, factor that in

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u/spain_receta1 point·2 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/andres_restrepo1 point·2 months ago

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

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u/ms_fragmenter1 point·2 months ago

IANAD and neither is anyone upvoting this

Adding to this: stability is doing more work than the comment implies.

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u/jarno_adeyemi125 points·2 months ago

Reconstituted or dry powder?

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u/ireland_drugs_pay66 points·2 months ago

Spain to Spain: 19 days with TFC and 19 days with WXT. Same route, different carriers, variance is real.

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u/milos_vestergaard45 points·2 months ago

customs clearance often breaks the cold chain, factor that in

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u/isabela_nilsen16 points·2 months ago

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

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u/emeka_beaulieu28 points·2 months ago

France to France takes 12 days on average, variance is 16 days

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[removed]19 points·2 months ago

[removed by moderator]

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u/brigade_detector12 points·2 months ago

Respectfully this is a sample of one presented as a finding.

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u/elodie_kuipers6 points·2 months ago·edited

[removed by moderator]

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/preservative_free_p49 points·2 months ago

Disagree. What you are describing is consistent with data logger, not with what you concluded.

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u/kian_ekstrom58 points·2 months ago

This is correct. Dry powder is way more robust than liquid.

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u/hplc_hobbyistruns their own column17 points·2 months ago

lane reports need origin, destination, carrier, and actual transit days

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u/nikhil_asante38 points·2 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/coldchain_karencold chain11 points·2 months ago·edited

The confident tone is doing a lot of work that the evidence is not.

Disagree on that part. 98.4% and 98.3% on the same vial is normal.

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u/meera_sandvik3 points·2 months ago

Strongly agree. Peak temperature is not the whole story.

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u/tomas_lokkenOP31 points·2 months ago

France to France takes 16 days on average, variance is 9 days

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u/tomas_lokkenOP23 points·2 months ago

The gel pack lasted 18 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.

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u/runa_wikstrom0 points·2 months ago

Strongly agree. Peak temperature is not the whole story.

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u/emeka_beaulieu1 point·2 months ago

Strongly agree.

Yes, exactly this, and it is the bit that took me 43 weeks to accept.

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u/prior_auth_painappeals0 points·2 months ago

no tracking numbers, no full addresses, no label photos — instant removal

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u/tomas_lokkenOP1 point·2 months ago

France to France: 12 days with ERP and 8 days with Homopeptide. Same route, different carriers, variance is real.

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u/rohan_steiner1 point·2 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/britt_okwuosa1 point·2 months ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/anya_salgado1 point·2 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/kofi_ferreira1 point·2 months ago

This is correct. Dry powder is way more robust than liquid.

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u/mod_cold_roommod · c/coldchain1 point·2 months ago

Strongly agree. Peak temperature is not the whole story.

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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c/coldchain rules
  1. Excursion claims need a logger trace or a photo taken at unboxing. "It felt warm" is not data.
  2. No tracking numbers, ever. They identify you and the recipient.
  3. Stability claims need a source or an explicit "this is my guess" label.
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  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
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