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Single comment threadYou are looking at one branch of the water content question that gets asked weekly, answered properly — 28 comments in the full submission. View in context.
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c/coa·submitted 1 months ago by u/coa_janitor

the water content question that gets asked weekly, answered properly

Labbranch of 11 comments

Quick one. Canada here. related substances works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 20 weeks and cost roughly what I expected. The admin was worse…

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This branch

11 comments, started 1 months ago
u/certified_referenceMOD290 points·1 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/janek_ferrari118 points·1 months ago

chromatogram or it did not happen

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u/liv_nkemelu228 points·1 months ago·edited

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/joaquin_ivaturi140 points·1 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/rohan_steiner129 points·1 months ago

Retitled to remove editorialising.

Yes, exactly this, and it is the bit that took me 25 weeks to accept.

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u/ismael_eriksen69 points·1 months ago

chromatogram or it did not happen

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u/ghrp_history34 points·1 months ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/sunday_shot_sal18 points·1 months ago

I am going to push back on this slightly.

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u/coa_janitorOPmod · c/coa13 points·1 months ago

Water content was 3.8%, acetate was 6.2%, purity was 99%, but net peptide was only 90% of the label weight. Perfectly honest, just chemistry.

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u/yusuf_nakamura220 points·1 months ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/isabela_nilsen259 points·1 months ago

Small correction: the trial was 9 weeks, not 15. Does not change your point but people will quote it.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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