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c/coa·posted 1 year ago by u/step_therapy_s

stalled for 9 weeks at 10mg and I refuse to panic this time

Question Receipts ×6 Cold Box ×1

water content. That is the whole post, but I will justify it.

Everything else people worry about in c/darkspot is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort water content out first, and almost nobody does.

I say this having got it wrong for 18 months. My A1c was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

2,011 up / 666 down75% upvoted26 commentsid 6gpt49 Nov 2024

26 comments

15 in this archive, depth 4

best — the order this archive was captured in

u/teodor_jansen-31 points·1 year ago

no "is this good?" without saying what the compound and claimed purity are

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u/gastric_emptying_g1 point·1 year ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/zaid_balogun157 points·1 year ago

no "is this good?" without saying what the compound and claimed purity are

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u/step_therapy_sOP0 points·1 year ago

no "is this good?" without saying what the compound and claimed purity are

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/janek_ferrari42 points·1 year ago

the related substances line is where the story is

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u/step_therapy_sOP25 points·1 year ago

the related substances line is where the story is

Yes, exactly this, and it is the bit that took me 10 weeks to accept.

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u/certified_referenceMOD90 points·1 year ago

Tracking number removed. It identifies both ends of a shipment.

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u/wrong_network_w37 points·1 year ago

Water content on the document? That affects your concentration math.

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u/karma_irrelevant123 points·1 year ago

the method line is doing real work, not just window dressing

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u/emeka_chowdhury79 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/emeka_beaulieu30 points·1 year ago

Cosigning. The batch number is load-bearing information.

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u/step_therapy_sOP51 points·1 year ago

redact your own name, not the vendor's batch details

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u/emeka_chowdhury116 points·1 year ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/cesar_ivaturi40 points·1 year ago

The COA I was holding said 96.8% area and I thought it was trash. Turns out the method was solid and the impurity profile was clean.

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u/foam_head_fred94 points·1 year ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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c/coa rules
  1. Post the full document. Cropped COAs that hide the batch number or date get removed.
  2. Redact your own name and order id, not the vendor's batch details.
  3. No "is this good?" without saying what the compound and claimed purity are.
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  5. Not medical advice. Describe what you did; never prescribe to a stranger.
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