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c/coa·posted 1 year ago by u/neha_erdogan

[Discussion] the purity advice in here is 9 years out of date

Discussion Slow Clap ×9 Well Actually ×2 Clean Column ×1

Posting this because I searched for it and got nothing useful.

Setup: 1.7mg, week 52, sulphur burps present but not ruining anything. I changed exactly one variable — COA — and tracked it for 9 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

3,502 up / 376 down90% upvoted49 commentsid 1todui27 Jul 2025

49 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/spreadsheet_gremlindata-30 points·1 year ago

Disagree. What you are describing is consistent with area percent, not with what you concluded.

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u/emeka_beaulieu1 point·1 year ago

no "is this good?" without saying what the compound and claimed purity are

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u/santiago_szabo1 point·1 year ago

Cosigning. The batch number is load-bearing information.

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u/aurel_boateng1 point·1 year ago·edited

the related substances line is where the story is

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u/liv_nkemelu0 points·1 year ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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[deleted]1 point·1 year ago

[deleted]

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u/coa_janitorMOD110 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/blunt_coldbox2977 points·1 year ago

Crossposting this to c/darkspot because the people who need it are not reading this community.

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u/cato_achebe0 points·1 year ago
source?
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u/alcohol_aversion1 point·1 year ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/neha_erdoganOP1 point·1 year ago

Strongly agree.

Adding to this: area percent is doing more work than the comment implies.

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u/neha_erdoganOP1 point·1 year ago

Asked QSC for the batch-specific COA and they sent it within six hours, full document, batch number, date, everything. That is the baseline.

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u/isabela_nilsen0 points·1 year ago

Cosigning. The batch number is load-bearing information.

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u/emeka_beaulieu25 points·1 year ago

This is the correct framing. The COA structure matters as much as the number.

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u/neha_erdoganOP10 points·1 year ago

The COA I was holding said 96.8% area and I thought it was trash. Turns out the method was solid and the impurity profile was clean.

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u/tidy_vialdrawer_pls8 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/freya_baptista4 points·1 year ago

no "is this good?" without saying what the compound and claimed purity are

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u/zeynep_zielinski21 points·1 year ago

The COA I was holding said 96.8% area and I thought it was trash. Turns out the method was solid and the impurity profile was clean.

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u/halima_boateng10 points·1 year ago

The COA I was holding said 96.8% area and I thought it was trash.

Adding to this: purity is doing more work than the comment implies.

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u/rania_okonkwo6 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/ahmed_rasmussen3 points·1 year ago

the related substances line is where the story is

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u/india_generic_g2 points·1 year ago

Cosigning. The batch number is load-bearing information.

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u/coa_collectorarchivist1 point·12 months ago

post the whole document, not the headline number

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u/laila_yilmaz12 points·1 year ago

The COA I was holding said 96.8% area and I thought it was trash.

Adding to this: batch is doing more work than the comment implies.

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u/hugo_bergstrom12 points·1 year ago

What is the method line say? Not the technique, the actual method.

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u/first_hundred9 points·1 year ago·edited

no "is this good?" without saying what the compound and claimed purity are

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u/chidi_demir5 points·1 year ago

Small correction: the trial was 3 weeks, not 24. Does not change your point but people will quote it.

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u/sunday_shot_sal8 points·1 year ago

What is the method line say?

Disagree on that part. 98.4% and 98.3% on the same vial is normal.

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u/nadia_kjaer9 points·1 year ago

This is the correct framing. The COA structure matters as much as the number.

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u/emeka_chowdhury3 points·1 year ago·edited

the method line is doing real work, not just window dressing

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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