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c/cagrilintide·submitted 22 days ago by u/pancreatitis_scare

[Caution] not approved anywhere. keep posts descriptive.

Cautionbranch of 6 comments

co-agonism. That is the whole post, but I will justify it. Everything else people worry about in c/vendorvetting is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort co-agonism out first, and almost nobody does. I say this having got it wrong for 15 months.…

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6 comments, started 21 days ago
u/rina_sobczak-27 points·21 days ago

Disagree. What you are describing is consistent with CagriSema, not with what you concluded.

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u/georgi_chowdhury1 point·20 days ago

REDEFINE which arm?

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u/runa_grimaldi1 point·21 days ago

long-acting amylin is co-agonism, different satiety profile

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u/hedda_aguirre1 point·20 days ago

not approved anywhere, keep posts descriptive, not instructional

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u/sequence_checkerresearch peptides1 point·20 days ago

amylin receptor distribution is different from GLP-1

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u/hugo_pires1 point·20 days ago

the amylin agonist pool is small, community is satiety

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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c/cagrilintide rules
  1. Amylin is not a GLP-1. Posts conflating them get corrected.
  2. CagriSema ratios in trials are fixed-dose. Do not extrapolate to self-mixing.
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