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c/cagrilintide·submitted 3 months ago by u/protein_first_p

[PSA] REDEFINE is not what most of this community thinks it is

Cautionbranch of 7 comments

Confession thread, sort of. I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 14 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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7 comments, started 3 months ago
u/lukas_vermeulen9 points·3 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/pancreatitis_scare7 points·3 months ago

tendon and CagriSema literature in rodents is interesting

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u/protein_first_pOPnutrition4 points·2 months ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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u/noor_ivaturi2 points·2 months ago

CagriSema is a fixed combo in trials, not user-mixed

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u/rafael_krastev-20 points·2 months ago

long-acting amylin is co-agonism, different satiety profile

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u/niels_norgaard1 point·2 months ago·edited

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/iman_castellanos7 points·3 months ago

Water content matters more than people think.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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