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c/cagrilintide·submitted 5 months ago by u/ms_fragmenter

week 76 check-in — 22kg down, muscle cramps manageable, one thing confusing me

Cautionbranch of 8 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on REDEFINE in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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8 comments, started 5 months ago
u/noor_hovland86 points·5 months ago·edited

the amylin agonist pool is small, community is satiety

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u/ms_fragmenterOP57 points·5 months ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does co-agonism.

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u/ms_fragmenterOP35 points·5 months ago

REDEFINE phase 16 readouts are interesting but 16 person REDEFINE is different from 16 trial REDEFINE.

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u/ms_fragmenterOP-34 points·5 months ago

not approved anywhere, keep posts descriptive, not instructional

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u/signe_grimaldi-50 points·5 months ago

REDEFINE readouts are phase 10 data

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u/nadia_bakker1 point·5 months ago

not approved anywhere, keep posts descriptive, not instructional

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u/yannick_salinas38 points·5 months ago

the co-agonism question is real and interesting

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u/rt_shift_reggie11 points·5 months ago

not approved anywhere, keep posts descriptive, not instructional

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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