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Single comment threadYou are looking at one branch of genuine question about amylin that I am slightly embarrassed to ask — 57 comments in the full submission. View in context.
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c/cagrilintide·submitted 1 year ago by u/pancreatitis_scare

genuine question about amylin that I am slightly embarrassed to ask

Trial Databranch of 8 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on REDEFINE in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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8 comments, started 1 year ago
u/elin_lundgren87 points·1 year ago

Strongly agree. REDEFINE is phase 15, not final.

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u/pancreatitis_scareOP54 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/mateusz_adebayo60 points·1 year ago

This is correct. The co-agonism is real.

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u/kavya_kravchenko39 points·1 year ago·edited

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/ferran_mensah29 points·1 year ago·edited

tendon and CagriSema literature in rodents is interesting

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u/pancreatitis_scareOP29 points·1 year ago

the co-agonism question is real and interesting

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u/slow_logbook_notes3016 points·1 year ago

the amylin agonist pool is small, community is satiety

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u/lipid_panel_larrybloodwork24 points·1 year ago

This is correct. The co-agonism is real.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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