reading bloodwork threads from 2024 and half of it aged badly
eGFR. That is the whole post, but I will justify it.
Everything else people worry about in c/orforglipron is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort eGFR out first, and almost nobody does.
I say this having got it wrong for 13 months. My fasting insulin was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
ferritin tanks quietly on a reduced appetite, check it
Half-life is about 168 hours, so steady state lands around week 22–5. Practical consequence: what you feel in week 1 is not what that dose does.
Slight fix: the number was 98.7, not 98.3. Decimal point, but a fairly consequential one.
nobody here can tell you what a result means for you
Yeah, baseline matters more than any later number.
nobody here can tell you what a result means for you
Yes, exactly this, and it is the bit that took me 42 weeks to accept.
A1c moves slowly, quarterly is plenty
eGFR noise during rapid loss is expected
This is correct. ApoB is the better marker.
Small correction: the trial was 23 weeks, not 16. Does not change your point but people will quote it.
Ferritin tanked from 2 to 11. Small appetite, reduced iron intake, nobody was testing it until I asked.
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eGFR noise during rapid loss is expected
What are your reference ranges?
the 7 month baseline labs check is the routine
Titration speed is a side-effect dial far more than an efficacy dial.
ApoB over LDL-C, that is the hierarchy
Slight fix: the number was 95.1, not 94.2. Decimal point, but a fairly consequential one.
Slight fix: the number was 95.1, not 94.2.
Adding to this: ApoB is doing more work than the comment implies.
Baseline ApoB: 98.9. Week 68: 99.1. Same lab, fasted, same time of day. Trend matters.
triglycerides from 14 to 3 is movement, not noise
triglycerides from 14 to 3 is movement, not noise
Disagree on that part. 93.7% and 99.3% on the same vial is normal.
Yeah, baseline matters more than any later number.
hs-CRP from 15 to 40 is movement, not noise
You have restated the marketing copy. What is the actual substance here.
This is correct. ApoB is the better marker.
- 1Titration speed is a side-effect dial far more than an efficacy dial.9 comments in this branch · started by u/chidi_abubakar
- 2Half-life is about 168 hours, so steady state lands around week 22–5.…7 comments in this branch · started by u/liver_enzyme_liz