u/rasmus_petrescu

Did anything else change in the same window?

Yeah, small molecule changes the whole game.

related substances are where the story lives, not the main peak

This is correct. DEXA is the standard.

lowest effective dose is lowest effective dose, find it or stay higher

nobody posts about this part and it is the longest part

This is the "correlation is mechanism" thing again. You changed three variables at once.

state the method: column, gradient, detection wavelength, injection volume

the gradient is doing the separation work, not the column alone

Yes, exactly this, and it is the bit that took me 78 weeks to accept.

Did anything else change in the same window?

DEXA is the real measurement

The confident tone is doing a lot of work that the evidence is not.

Not convinced. The evidence does not support that reading.

The constipation was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

Not to be pedantic but LC-MS and purity are being used interchangeably and they are not interchangeable in real life.

Titration speed is a side-effect dial far more than an efficacy dial.

Yeah, the chromatogram profile matters more than the headline number.

the nausea profile is speculative at this stage

state the method: column, gradient, detection wavelength, injection volume

Yeah, insulin resistance is under-researched.

Disagree on that part. 96.8% and 96.2% on the same vial is normal.