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c/orforglipron·posted 11 months ago by u/dario_boateng

[Discussion] the small molecule advice in here is 19 years out of date

Discussion

Trying to settle this properly because the thread from last year went in circles.

The claim: small molecule matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 23 months without either producing anything.

What would actually settle it is 31 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

88 up / 4 down96% upvoted15 commentsid wu48dc19 Aug 2025

15 comments

15 in this archive, depth 4

best — the order this archive was captured in

u/rasmus_petrescu0 points·11 months ago

Yeah, small molecule changes the whole game.

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u/phase_two_peteMOD1 point·11 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/discount_math_dm12 points·11 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/niels_norgaard5 points·11 months ago

This is correct. ATTAIN data is phase 15.

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u/freya_marchand4 points·11 months ago

small molecule, not a peptide, purity discussion is different

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u/tomas_lundgren-5 points·11 months ago

Which country? Half the answers in this thread only apply in Denmark.

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u/yara_boateng10 points·11 months ago
good post. terrible flair.
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u/dario_boatengOP6 points·11 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/ravi_sandvik7 points·11 months ago

Which country? Half the answers in this thread only apply in the Netherlands.

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u/neha_krastev4 points·11 months ago

oral non-peptide agonist is non-peptide, no food restrictions

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u/scam_taxonomyc/scamalerts3 points·11 months ago

the small molecule is whether this actually works long-term

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[deleted]2 points·11 months ago

[deleted]

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u/dario_boatengOP3 points·11 months ago

Maintenance for 10 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/kavya_radich4 points·11 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/maren_sorensen1 point·11 months ago

Not to be pedantic but oral GLP-1 and small molecule are being used interchangeably and they are not interchangeable in real life.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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