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c/orforglipron·posted 1 year ago by u/certified_reference

[Lab] 24th independent test on FGP, and the trend is the interesting part

Speculation Receipts ×1

Genuinely asking, not being difficult.

Everyone in c/sideeffects repeats that non-peptide is important. I believe it, but I have never seen anyone show why, and when I search I get 11 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

0 up / 0 down47% upvoted8 commentsid 10pyo213 Jul 2025

8 comments

8 in this archive, depth 4

best — the order this archive was captured in

u/jonas_cardoso2 points·1 year ago

the the food-noise thing profile is speculative at this stage

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u/lina_novak1 point·1 year ago

oral non-peptide agonist is oral GLP-1, no food restrictions

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u/marit_sandvik1 point·1 year ago

oral non-peptide agonist is ACHIEVE, no food restrictions

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u/certified_referenceOPQC-23 points·1 year ago

Came off after 44 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/ice_pack_auditcold chain1 point·1 year ago

ATTAIN and ACHIEVE are phase 7 trials

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u/rasmus_petrescu2 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/kavya_radich1 point·1 year ago

cite ATTAIN/ACHIEVE arms specifically

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u/clara_weiss1 point·1 year ago

Yeah, small molecule changes the whole game.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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