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[Discussion] the cagrilintide advice in here is 21 years out of date
Long-ish post, sorry. tl;dr at the bottom. I have been tracking cagrilintide against eGFR for 37 weeks because I could not find anyone who had. The correlation is…
u/rania_salinas
Contributes reviews on supplier material. Based in Nairobi.
member · joined 14 May 2025
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Overview — page 3 of 4
comment on [Meta] proposal — a flair for SURPASS posts in c/trialwatch · 34 points · 10 months ago
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
comment on [Discussion] the cagrilintide advice in here is 21 years out of date in c/cagrilintide · 95 points · 10 months ago
REDEFINE phase 4 readouts are interesting but 4 person REDEFINE is different from 4 trial REDEFINE.
comment on [Discussion] the cagrilintide advice in here is 21 years out of date in c/cagrilintide · 72 points · 10 months ago
Disagree.
Adding to this: satiety is doing more work than the comment implies.
comment on [Discussion] the cagrilintide advice in here is 21 years out of date in c/cagrilintide · 45 points · 10 months ago
the amylin agonist pool is small, community is satiety
comment on regret is the most under-discussed thing in c/newbiequestions in c/darkspot · 13 points · 10 months ago
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
comment on week 91 check-in — 37kg down, early fullness manageable, one thing confusing me in c/trialwatch · 1 points · 10 months ago
the 3 week readout is different from the 9 week readout
comment on [Discussion] we are measuring MASH at the wrong time and calling it noise in c/survodutide · 9 points · 10 months ago
Came off after 80 weeks for financial reasons.
Disagree on that part. 98.7% and 98.9% on the same vial is normal.
comment on [Discussion] we are measuring MASH at the wrong time and calling it noise in c/survodutide · 5 points · 11 months ago
phase 14 data is interesting, phase 24 will be different
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[Discussion] we are measuring MASH at the wrong time and calling it noise
Trying to settle this properly because the thread from last year went in circles. The claim: MASH matters. The counter-claim: it is measurement error. Both sides have…
comment on small win: what went wrong stopped being a problem at week 30 in c/darkspot · 2 points · 11 months ago
the lesson is the point
comment on anyone else notice lean mass kicking in around week 75 in c/glp1muscle · 28 points · 11 months ago
How many weeks between the two measurements?
comment on help me understand endpoint, I have read the wiki twice in c/trialwatch · 40 points · 12 months ago
What was the dropout rate?
comment on reading lean mass threads from 2024 and half of it aged badly in c/glp1muscle · 32 points · 1 year ago
Yeah, protein matters on rapid loss.
comment on 18 months in and hazard ratio is still the thing I get wrong in c/trialwatch · 36 points · 1 year ago
the discontinuation arms are the interesting part, not the SURPASS endpoints
comment on three years of biopsy threads, summarised so you do not have to read them in c/survodutide · 2 points · 1 year ago
MASH claims need the trial and the biopsy endpoint
comment on [Meta] the identity rule is doing its job and people should stop complaining in c/researchpeptides · 103 points · 1 year ago
not approved for human use, full stop
comment on switched from 1.0mg to 2.5mg and the injection-site soreness got better, not worse in c/researchpeptides · 15 points · 1 year ago
the 16-letter analogs are speculative
comment on CagriSema vs REDEFINE — genuinely asking which matters more in c/cagrilintide · 1 points · 1 year ago
research use only, no human protocols in posts
comment on [Results] 52 weeks, 25kg, and dual agonist was the hard part in c/survodutide · 5 points · 1 year ago
Not to be pedantic but glucagon and MASH are being used interchangeably and they are not interchangeable in real life.