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c/darkspot·posted 10 months ago by u/yusuf_achebe

regret is the most under-discussed thing in c/newbiequestions

Resolved Receipts ×1 Well Actually ×2

Confession thread, sort of.

I went from 10mg to 2.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 6 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 2 reads it before doing the same thing.

1,163 up / 251 down82% upvoted59 commentsid 4c21z113 Sep 2025

59 comments

27 in this archive, depth 5

best — the order this archive was captured in

u/yusuf_achebe59 points·10 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/quarter_dose_queenlow and slow33 points·10 months ago

the 20 order that disappeared from GL Biochem

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u/burned_once_twiceMOD58 points·10 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/appeal_letter_al45 points·10 months ago

Second this question. I have wondered about lost money for 21 months and never seen a straight answer.

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u/quarter_dose_queenlow and slow39 points·10 months ago·edited

Came off after 8 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/sterile_field_steph15 points·10 months ago

Did anything else change in the same window?

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[removed]11 points·10 months ago

[removed by moderator]

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u/marisol_frisk0 points·10 months ago

Removed a chain here.

Disagree on that part. 97.4% and 95.1% on the same vial is normal.

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u/endpoint_creep33 points·10 months ago

money lost to group buys

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u/yusuf_achebe26 points·10 months ago

Ireland here. Waited 16 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/yusuf_achebeOP10 points·10 months ago

Maintenance for 12 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/incretin_ivypharmacology23 points·10 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/sterile_field_steph12 points·10 months ago

Half-life is about 168 hours, so steady state lands around week 3–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/incretin_ivypharmacology5 points·10 months ago

Strongly agree. No piling on.

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u/rasmus_kimani10 points·10 months ago

failures, regrets, things that went wrong

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u/anders_osei2 points·10 months ago

failures, regrets, things that went wrong

Disagree on that part. 99.0% and 98.9% on the same vial is normal.

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u/slow_logbook1 point·10 months ago

Strongly agree. No piling on.

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u/emil_wojcik6 points·10 months ago

money lost to group buys

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u/rania_salinas13 points·10 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/two_mil_or_one11 points·10 months ago

Small correction: the trial was 11 weeks, not 30. Does not change your point but people will quote it.

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u/lane_map_larrylogistics7 points·10 months ago

Slight fix: the number was 98.7, not 98.7. Decimal point, but a fairly consequential one.

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u/fabio_ibarra9 points·10 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/burned_once_twice11 points·10 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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About c/darkspot

Where the failure reports live. Orders that never arrived, tests that came back at 61%, side effects that ended someone's run, money lost to group buys, and decisions people would not make again. Heavily moderated for cruelty, not for pessimism.

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