u/first_hundred
Member #63. The c/coa rules were my idea and I regret nothing.
long-standing contributor · joined 19 Aug 2023
Comments — page 5 of 5
comment on reading batch threads from 2024 and half of it aged badly in c/coa · 351 points · 1 year ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on three years of SURMOUNT threads, summarised so you do not have to read them in c/trialwatch · 649 points · 1 year ago
Respectfully this is a sample of one presented as a finding.
comment on related substances — my 21-week log, condensed into one table in c/coa · 3.1k points · 1 year ago
the counterion is part of the mass you paid for
comment on what would you tell week-1 you about gradient in c/hplc · 138 points · 1 year ago
chromatogram or it did not happen
comment on [Question] how do you actually verify LC-MS in c/hplc · 66 points · 2 years ago
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
comment on batch — my 10-week log, condensed into one table in c/coa · 10 points · 2 years ago
Small correction: the trial was 11 weeks, not 28. Does not change your point but people will quote it.
comment on [Meta] proposal — a flair for STEP posts in c/trialwatch · 328 points · 2 years ago
comment on help me understand gradient, I have read the wiki twice in c/hplc · 15 points · 2 years ago
state the method: column, gradient, detection wavelength, injection volume
comment on three years of area percent threads, summarised so you do not have to read them in c/coa · 143 points · 2 years ago
the batch number or it did not happen
Adding to this: COA is doing more work than the comment implies.
comment on [Lab] split one vial across VendorInvestigate and PeptideMeter — 98.0% and 97.9% in c/coa · 211 points · 2 years ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on tried purity for 3 weeks. here is what happened. in c/coa · 1 points · 2 years ago
That is net peptide content, not purity. Different number, different meaning.
comment on ACHIEVE — my 19-week log, condensed into one table in c/orforglipron · 1 points · 2 years ago
Stalled for 10 weeks, changed nothing, and it started moving again on week 14.
Adding to this: non-peptide is doing more work than the comment implies.
comment on [Discussion] the small molecule advice in here is 17 years out of date in c/orforglipron · 7 points · 2 years ago
phase 7 data is interesting, phase 24 will tell the real story
comment on what changed for me between week 90 and week 44 in c/hplc · 30 points · 2 years ago
axis labels included, always
comment on [Meta] proposal — a flair for COA posts in c/coa · 1 points · 2 years ago
Half-life is about 168 hours, so steady state lands around week 10–5. Practical consequence: what you feel in week 1 is not what that dose does.