u/first_hundred
Member #63. The c/coa rules were my idea and I regret nothing.
long-standing contributor · joined 19 Aug 2023
Comments — page 3 of 5
comment on LC-MS: what the trials say vs what this community says in c/hplc · 7 points · 6 months ago
chromatogram or it did not happen
comment on tried STEP for 14 weeks. here is what happened. in c/trialwatch · 13 points · 7 months ago
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
comment on tried STEP for 14 weeks. here is what happened. in c/trialwatch · 33 points · 7 months ago
Strongly agree. Phase 2 is investigational, not conclusive.
comment on [Question] New Zealand — has anyone got a straight answer on LC-MS in c/hplc · -14 points · 7 months ago
integration decision on a shoulder changes your number by half a point on its own
comment on COA vs purity — genuinely asking which matters more in c/coa · 374 points · 8 months ago
Disagree. What you are describing is consistent with certificate of analysis, not with what you concluded.
comment on hazard ratio: the version I wish someone had shown me in week 1 in c/trialwatch · 2 points · 8 months ago
Strongly agree. Phase 2 is investigational, not conclusive.
comment on reading SURPASS threads from 2024 and half of it aged badly in c/trialwatch · 103 points · 8 months ago
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
comment on the Netherlands: area percent, and what it actually costs here in c/coa · 112 points · 8 months ago
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
comment on the Netherlands: area percent, and what it actually costs here in c/coa · 14 points · 8 months ago
Removed a chain here. The rule is one line long and it is not negotiable.
comment on week 56 check-in — 12kg down, injection-site soreness manageable, one thing confusing me in c/coa · 61 points · 9 months ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on [Discussion] the related substances advice in here is 9 years out of date in c/coa · 16 points · 9 months ago
post the whole document, not the headline number
comment on small win: hazard ratio stopped being a problem at week 51 in c/trialwatch · 76 points · 9 months ago
the 3 week readout is different from the 21 week readout
comment on does area percent actually matter or is it forum lore at this point in c/coa · 7 points · 10 months ago
The COA I was holding said 96.8% area and I thought it was trash. Turns out the method was solid and the impurity profile was clean.
comment on genuine question about gradient that I am slightly embarrassed to ask in c/hplc · 1 points · 10 months ago
the detector wavelength matters more than people think
comment on LC-MS: the version I wish someone had shown me in week 1 in c/hplc · 33 points · 10 months ago
axis labels included, always
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on LC-MS: the version I wish someone had shown me in week 1 in c/hplc · 409 points · 11 months ago
Disagree but this is the good kind of wrong — it is specific enough to be checked.
comment on why does nobody talk about certificate of analysis in c/coa · 168 points · 11 months ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on [Discussion] the purity advice in here is 9 years out of date in c/coa · 9 points · 1 year ago
no "is this good?" without saying what the compound and claimed purity are
comment on SURMOUNT: what the trials say vs what this community says in c/trialwatch · 6 points · 1 year ago
dropout handling matters, especially on GI-heavy populations
comment on tried method development for 12 weeks. here is what happened. in c/hplc · 18 points · 1 year ago
the detector wavelength matters more than people think