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c/trialwatch·submitted 11 months ago by u/pancreatitis_scare

why does nobody talk about SELECT

Trial Databranch of 5 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on TRIUMPH in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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5 comments, started 11 months ago
u/renal_outcomes_rnephro-curious57 points·11 months ago

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

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u/alcohol_aversion26 points·11 months ago

phase 2 is not phase 3, smaller n and shorter trial

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u/milos_trevino18 points·11 months ago·edited

This is correct. Discontinuation arms show the regain reality.

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u/pancreatitis_scareOP23 points·11 months ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

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u/naomi_ekstrom9 points·11 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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