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c/trialwatch·submitted 2 years ago by u/joaquin_trevino

[Results] 77 weeks, 21kg, and endpoint was the hard part

Trial Databranch of 6 comments

Week 55 update. 31kg down from the start, muscle cramps basically gone since about week 95. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps. The part that surprised me is how much of this is admin.…

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6 comments, started 2 years ago
u/rina_bergstrom131 points·2 years ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/week_one_wanda80 points·2 years ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

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u/hsa_math33 points·2 years ago

phase 2 is not phase 3, smaller n and shorter trial

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u/milos_vanhecke50 points·2 years ago

phase 2 is not phase 3, smaller n and shorter trial

Disagree on that part. 99.2% and 99.0% on the same vial is normal.

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u/pancreatitis_scare0 points·2 years ago

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

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[deleted]1 point·2 years ago

[deleted]

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