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c/trialwatch·posted 1 months ago by u/hedda_adeyemi

[Discussion] the SURPASS advice in here is 9 years out of date

Discussion Cold Box ×3 Slow Clap ×1

Confession thread, sort of.

I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 18 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 2 reads it before doing the same thing.

1,088 up / 174 down86% upvoted19 commentsid 147sxh13 Jun 2026

19 comments

5 in this archive, depth 3

best — the order this archive was captured in

u/renal_outcomes_rMOD122 points·1 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/anders_kuusela29 points·1 months ago

Flair changed to match the content.

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

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u/customs_seizure_sid74 points·1 months ago
genuinely useful, thanks
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u/line_demir55 points·1 months ago

the discontinuation arms are the interesting part, not the SURPASS endpoints

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u/heart_rate_bump45 points·1 months ago

the relative risk reduction in headlines is not the whole story

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