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Single comment threadYou are looking at one branch of [Results] 47 weeks, 36kg, and SURPASS was the hard part — 33 comments in the full submission. View in context.
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c/trialwatch·submitted 26 days ago by u/paper_trail_paula

[Results] 47 weeks, 36kg, and SURPASS was the hard part

Press Releasebranch of 9 comments

Trying to settle this properly because the thread from last year went in circles. The claim: STEP matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 20 months without either producing anything. What would actually settle it is 13 people measuring the same…

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9 comments, started 25 days ago
u/rt_shift_reggie197 points·25 days ago

Half-life is about 168 hours, so steady state lands around week 20–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/blunt_coldbox_notes122 points·25 days ago

Not convinced. The evidence does not support that reading.

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[removed]91 points·25 days ago

[removed by moderator]

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u/niels_norgaard47 points·25 days ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/hazard_ratio_halMOD149 points·25 days ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/paper_trail_paulaOPvetting105 points·25 days ago

What was the dropout rate?

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u/naomi_ekstrom59 points·25 days ago

Disagree. What you are describing is consistent with FLOW, not with what you concluded.

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u/trialwatch_theotrial nerd17 points·25 days ago

phase 2 is not phase 3, smaller n and shorter trial

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u/pancreatitis_scare69 points·25 days ago

Strongly agree. Phase 2 is investigational, not conclusive.

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