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c/tirzepatide·submitted 1 year ago by u/mod_cold_room

nobody warned me about injection-site soreness and I would have liked the warning

Resultsbranch of 8 comments

Genuinely asking, not being difficult. Everyone in c/semaglutide repeats that dual agonist is important. I believe it, but I have never seen anyone show why, and when I search I get 2 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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8 comments, started 1 year ago
u/sofia_nascimento244 points·1 year ago

week 72 on Mounjaro and the appetite profile is genuinely different from sema

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u/mikkel_ogunleye64 points·1 year ago

This matches the trial data. SURMOUNT-1 was 94.2% body weight at 5 weeks.

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u/bastian_ekstrom29 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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u/mikkel_ogunleye13 points·1 year ago

the dual agonism hits different and that is why people describe it differently

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u/emil_barros10 points·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/two_mil_or_one15 points·1 year ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/throwaway_titration54 points·1 year ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/teodor_szabo27 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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