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Single comment threadYou are looking at one branch of [Vendor] WXT order #2 — France, 33 days, no drama, receipts inside — 65 comments in the full submission. View in context.
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c/tirzepatide·submitted 1 year ago by u/throwaway_wl2026

[Vendor] WXT order #2 — France, 33 days, no drama, receipts inside

Trial Databranch of 7 comments

Trying to settle this properly because the thread from last year went in circles. The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 20 months without either producing anything. What would actually settle it is 19 people measuring the same…

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7 comments, started 1 year ago
u/elin_varga134 points·1 year ago·edited

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/aurel_lindqvist0 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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u/hugo_bergstrom1 point·1 year ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/bastian_eriksen0 points·1 year ago

dual agonism is SURPASS, do not generalise from semaglutide

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u/dexa_twice_yearlyMOD77 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/emil_okwuosa19 points·1 year ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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u/endpoint_creep13 points·1 year ago

Did you stay on semaglutide or switch?

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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