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c/tirzepatide·submitted 1 year ago by u/samir_falk

[Vendor] Homopeptide vs QSC on the same compound, same month, one test each

Discussionbranch of 6 comments

Trying to settle this properly because the thread from last year went in circles. The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 24 months without either producing anything. What would actually settle it is 35 people measuring the same…

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6 comments, started 1 year ago
u/slow_logbook_ftw209 points·1 year ago·edited

do not crack the pen, we have been over this

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u/tarek_lokken108 points·1 year ago

I am going to push back on this slightly.

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u/emil_okwuosa126 points·1 year ago

the dual agonism hits different and that is why people describe it differently

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u/spain_receta61 points·1 year ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/quiet_moderatormod93 points·1 year ago·edited

SURMOUNT data is messier than STEP data but the weight loss is there

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u/incretin_ivypharmacology100 points·1 year ago

do not crack the pen, we have been over this

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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