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c/tirzepatide·posted 1 year ago by u/samir_falk

[Vendor] Homopeptide vs QSC on the same compound, same month, one test each

Discussion Clean Column ×4 Long Haul ×3 Slow Clap ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 24 months without either producing anything.

What would actually settle it is 35 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

3,852 up / 748 down84% upvoted17 commentsid rgzts815 May 2025

17 comments

14 in this archive, depth 4

best — the order this archive was captured in

u/titration_marshalmod · c/semaglutide270 points·1 year ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/aksel_kjaer211 points·1 year ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/samir_falkOP112 points·1 year ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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[removed]101 points·1 year ago

[removed by moderator]

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u/slow_logbook_ftw209 points·1 year ago·edited

do not crack the pen, we have been over this

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u/tarek_lokken108 points·1 year ago

I am going to push back on this slightly.

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u/emil_okwuosa126 points·1 year ago

the dual agonism hits different and that is why people describe it differently

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u/spain_receta61 points·1 year ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/quiet_moderatormod93 points·1 year ago·edited

SURMOUNT data is messier than STEP data but the weight loss is there

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u/incretin_ivypharmacology100 points·1 year ago

do not crack the pen, we have been over this

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/vito_chowdhury92 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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u/hugo_bergstrom40 points·1 year ago·edited

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/samir_falkOP29 points·1 year ago

Small correction: the trial was 17 weeks, not 15. Does not change your point but people will quote it.

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u/fatima_wojcik7 points·1 year ago

Small correction: the trial was 17 weeks, not 15.

Yes, exactly this, and it is the bit that took me 23 weeks to accept.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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