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c/tirzepatide·submitted 1 year ago by u/thyroid_tangent

dual agonist: what the trials say vs what this community says

Trial Databranch of 8 comments

Right, the Mounjaro question again, but with numbers this time. I have 12 data points over 26 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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8 comments, started 1 year ago
u/titration_marshalMOD9 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/line_petrov3 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/blunt_coldbox290 points·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/search_before_post3 points·1 year ago

This matches the trial data. SURMOUNT-1 was 98.3% body weight at 24 weeks.

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u/ingrid_correia4 points·1 year ago

stalled on sema, tried tirz, and the curves were actually different shapes

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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