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c/tirzepatide·submitted 1 year ago by u/gentle_correction

tried tirzepatide for 24 weeks. here is what happened.

Side Effectsbranch of 6 comments

Posting this because I searched for it and got nothing useful. Setup: 2.4mg, week 14, injection-site soreness present but not ruining anything. I changed exactly one variable — SURPASS — and tracked it for 16 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted…

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This branch

6 comments, started 1 year ago
u/taper_off_tabitha401 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/b12_baseline331 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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u/nabila_ogunleye0 points·1 year ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

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u/gentle_correctionOPnice about it179 points·1 year ago

The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.

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u/gentle_correctionOPnice about it0 points·1 year ago

week 73 on Mounjaro and the appetite profile is genuinely different from sema

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[removed]85 points·1 year ago

[removed by moderator]

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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