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c/tirzepatide·submitted 12 months ago by u/santiago_villalobos

GIP: what the trials say vs what this community says

Questionbranch of 5 comments

Confession thread, sort of. I went from 10mg to 2.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 3 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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5 comments, started 12 months ago
u/laila_wikstrom312 points·12 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/curious_panel_only152 points·12 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/graph_it_gary124 points·12 months ago·edited

Not to be pedantic but Zepbound and SURPASS are being used interchangeably and they are not interchangeable in real life.

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u/copay_card_cc60 points·11 months ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

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u/santiago_villalobosOP81 points·11 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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