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c/tirzepatide·submitted 10 months ago by u/quiet_moderator

switched from 12.5mg to 10mg and the nausea got better, not worse

Side Effectsbranch of 6 comments

I have had 12 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 34 days on nominally the same lane, which matters more in summer than in February. The independent number came back 93.7% against a claimed…

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6 comments, started 10 months ago
u/priya_guerrero164 points·10 months ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/rania_marchand112 points·10 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/bastian_ekstrom35 points·10 months ago·edited

the GIP side does different things than the GLP-1 side, that is the point

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/cato_girard78 points·10 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/quiet_moderatorOPmod107 points·10 months ago·edited

Vial-splitting is on-topic here.

Yes, exactly this, and it is the bit that took me 37 weeks to accept.

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u/kaia_cabrera71 points·10 months ago·edited

This is the "correlation is mechanism" thing again. You changed three variables at once.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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