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c/tirzepatide·posted 10 months ago by u/quiet_moderator

switched from 12.5mg to 10mg and the nausea got better, not worse

Side Effects Receipts ×6 Cold Box ×1 Well Actually ×1

I have had 12 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 34 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 93.7% against a claimed 98.6%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

8,093 up / 3,049 down73% upvoted67 commentsid qcv40e9 Sep 2025

67 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/incretin_ivyMOD893 points·10 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/hair_shed_hannah240 points·10 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/emil_barros622 points·10 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/quiet_moderatorOPmod352 points·10 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/gustav_vermeulen89 points·10 months ago

I am going to push back on this slightly.

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u/vito_chowdhury48 points·10 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/amara_halonen38 points·10 months ago

the GIP side does different things than the GLP-1 side, that is the point

Yes, exactly this, and it is the bit that took me 67 weeks to accept.

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u/kofi_balogun33 points·10 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/ahmed_iyer559 points·10 months ago·edited

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/bastian_eriksen364 points·10 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/nz_unfunded448 points·10 months ago·edited

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/matias_salgado298 points·10 months ago

I am going to push back on this slightly.

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u/emil_wojcik245 points·10 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/throwaway_titration260 points·10 months ago·edited

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/tarek_lokken63 points·10 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/cato_girard50 points·10 months ago

Slight fix: the number was 99.0, not 98.9. Decimal point, but a fairly consequential one.

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u/priya_guerrero164 points·10 months ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/rania_marchand112 points·10 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/bastian_ekstrom35 points·10 months ago·edited

the GIP side does different things than the GLP-1 side, that is the point

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/cato_girard78 points·10 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/quiet_moderatorOPmod107 points·10 months ago·edited

Vial-splitting is on-topic here.

Yes, exactly this, and it is the bit that took me 37 weeks to accept.

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u/kaia_cabrera71 points·10 months ago·edited

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/signe_villalobos-10 points·10 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/matias_salgado1 point·10 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/b12_baseline1 point·10 months ago

How long at each step before you escalated?

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[deleted]1 point·10 months ago

[deleted]

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u/quiet_moderatorOPmod1 point·10 months ago

My hs-CRP moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/tove_vasquez72 points·10 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/gustav_vermeulen56 points·10 months ago

How long at each step before you escalated?

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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