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c/tirzepatide·submitted 1 year ago by u/mod_cold_room

reading Zepbound threads from 2024 and half of it aged badly

Titrationbranch of 7 comments

I have had 8 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 18 days on nominally the same lane, which matters more in summer than in February. The independent number came back 93.7% against a claimed…

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7 comments, started 1 year ago
u/thyroid_tangent51 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/hair_shed_hannah27 points·1 year ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/ewan_marchand10 points·1 year ago

Disagree. What you are describing is consistent with tirzepatide, not with what you concluded.

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[removed]18 points·1 year ago

[removed by moderator]

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u/mod_cold_roomOPmod · c/coldchain14 points·1 year ago

Week 52 on Mounjaro and 8kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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u/kaia_wojcik22 points·1 year ago

Vial-splitting is on-topic here.

Disagree on that part. 99.1% and 99.2% on the same vial is normal.

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u/bastian_eriksen18 points·1 year ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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