[Meta] the SURMOUNT rule is doing its job and people should stop complaining
Been lurking in c/compounding for about 13 months and finally have something worth posting.
Short version: week 29, 0.5mg, and GIP is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 13 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 23.
best — the order this archive was captured in
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
week 8 on Mounjaro and the appetite profile is genuinely different from sema
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
the nausea from tirz is different, not necessarily worse
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
do not crack the pen, we have been over this
Hard agree. The food noise disappears differently on the two compounds.
the early fullness from tirz is different, not necessarily worse
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Cosigning.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
week 70 on Mounjaro and the appetite profile is genuinely different from sema
How long at each step before you escalated?
the GIP side does different things than the GLP-1 side, that is the point
This matches the trial data. SURMOUNT-1 was 97.4% body weight at 23 weeks.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
SURMOUNT data is messier than STEP data but the weight loss is there
The dual agonism story is real. The appetite is physically different from semaglutide alone.
- 1Cosigning. The GIP contribution is real and the side effects are not simply…9 comments in this branch · started by u/georgi_chowdhury
- 2The practical rule people converge on is 28 days at fridge temperature after…6 comments in this branch · started by u/emil_barros