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c/tirzepatide·submitted 10 months ago by u/bastian_ekstrom

nobody warned me about sulphur burps and I would have liked the warning

Trial Databranch of 9 comments

Trying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 21 months without either producing anything. What would actually settle it is 35 people measuring the…

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This branch

9 comments, started 10 months ago
u/titration_marshalMOD853 points·10 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/bastian_ekstromOP483 points·10 months ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/elin_varga357 points·10 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/hassan_nilsen-21 points·10 months ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

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u/tidy_vialdrawer_pls628 points·10 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/bastian_ekstromOP379 points·10 months ago

Tried both. Sema worked, tirz worked better for me, but my sulphur burps profile was worse on tirz.

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u/sofia_nascimento263 points·10 months ago

week 40 on Mounjaro and the appetite profile is genuinely different from sema

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u/mikkel_kimani315 points·10 months ago

the 15mg is the top of the pen, not the required dose

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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