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c/tirzepatide·submitted 8 months ago by u/ignacio_vanhecke

[Vendor] QST order #8 — Spain, 33 days, no drama, receipts inside

Resultsbranch of 14 comments

Genuinely asking, not being difficult. Everyone in c/bloodwork repeats that GIP is important. I believe it, but I have never seen anyone show why, and when I search I get 11 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it has…

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14 comments, started 8 months ago
u/samir_falk385 points·8 months ago

Tried both. Sema worked, tirz worked better for me, but my reflux profile was worse on tirz.

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u/georgi_chowdhury132 points·8 months ago·edited

the GIP side does different things than the GLP-1 side, that is the point

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u/sofia_nascimento55 points·8 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/tarek_kirchner292 points·8 months ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/discount_math_dm237 points·8 months ago·edited

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/rania_diallo190 points·8 months ago

Respectfully this is a sample of one presented as a finding.

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u/ignacio_vanheckeOP287 points·8 months ago

My TSH moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/ferritin_low-37 points·8 months ago

Is that on Mounjaro pens or research tirzepatide?

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u/hair_shed_hannah224 points·8 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/throwaway_titration138 points·8 months ago

You have restated the marketing copy. What is the actual substance here.

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u/ignacio_vanheckeOP220 points·8 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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