GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of [Titration] 12 weeks per step is not too slow, it is just unfashionable — 53 comments in the full submission. View in context.
1.8k
c/tirzepatide·submitted 15 days ago by u/elin_varga

[Titration] 12 weeks per step is not too slow, it is just unfashionable

Titrationbranch of 8 comments

Quick one. Canada here. Zepbound works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 17 weeks and cost roughly what I expected. The admin was worse than the…

Read the full submission and all 53 comments →

This branch

8 comments, started 14 days ago
u/line_petrov47 points·14 days ago

SURMOUNT data is messier than STEP data but the weight loss is there

replysharereportpermalink
u/ingrid_correia33 points·14 days ago

SURMOUNT data is messier than STEP data but the weight loss is there

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

replysharereportpermalink
u/nordic_pricing19 points·14 days ago

SURMOUNT data is messier than STEP data but the weight loss is there

replysharereportpermalink
u/throwaway_wl202610 points·14 days ago·edited

dual agonism is SURPASS, do not generalise from semaglutide

replysharereportpermalink
u/thyroid_tangent11 points·13 days ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

replysharereportpermalink
u/adnan_nascimento32 points·14 days ago

This matches the trial data. SURMOUNT-1 was 93.7% body weight at 18 weeks.

replysharereportpermalink
u/hair_shed_hannah38 points·14 days ago

the dual agonism hits different and that is why people describe it differently

replysharereportpermalink
load more comments (1) →

← back to the whole thread

About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

187kmembers
130submissions
Aug 2023created
submissions / month, last year
Sponsored

Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

janoshik.comSponsored

GL Biochem (Shanghai)

Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

glbiochem.net
More in c/tirzepatide
c/tirzepatide rules
  1. "Tirz is better than sema" needs a comparator dose or it is a vibe, not a claim.
  2. Vial-splitting and self-compounding discussion stays in c/reconstitution.
  3. No pen-cracking tutorials. Discussing that people do it is fine; instructions are not.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/titration_marshalu/incretin_ivyu/quiet_moderatoru/dexa_twice_yearly
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →