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c/tirzepatide·submitted 6 months ago by u/elin_varga

[Discussion] we are measuring tirzepatide at the wrong time and calling it noise

Discussionbranch of 5 comments

Week 53 update. 4kg down from the start, muscle cramps basically gone since about week 10. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps. The part that surprised me is how much of this is admin.…

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5 comments, started 6 months ago
u/yusuf_ramos153 points·6 months ago

Switched from sema at 7.5mg to tirz at 5mg. Different drugs, cannot compare the doses directly.

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u/titration_marshalmod · c/semaglutide118 points·6 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/laila_wikstrom71 points·6 months ago

the 15mg is the top of the pen, not the required dose

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u/quiet_moderatorMOD87 points·6 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/elin_vargaOP48 points·6 months ago

Retitled to remove editorialising.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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