GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of [Discussion] we are measuring 15mg at the wrong time and calling it noise — 54 comments in the full submission. View in context.
3.4k
c/tirzepatide·submitted 7 months ago by u/mikkel_ogunleye

[Discussion] we are measuring 15mg at the wrong time and calling it noise

Discussionbranch of 10 comments

Right, the Mounjaro question again, but with numbers this time. I have 17 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

Read the full submission and all 54 comments →

This branch

10 comments, started 7 months ago
u/titration_marshalMOD528 points·7 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

replysharereportpermalink
u/line_petrov418 points·7 months ago

Not convinced. The evidence does not support that reading.

replysharereportpermalink
u/mikkel_ogunleyeOP330 points·7 months ago

Tried both. Sema worked, tirz worked better for me, but my early fullness profile was worse on tirz.

replysharereportpermalink
[deleted]365 points·6 months ago

[deleted]

replysharereportpermalink
u/elin_ferrari236 points·6 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

replysharereportpermalink
u/ingrid_correia145 points·6 months ago

week 57 on Mounjaro and the appetite profile is genuinely different from sema

replysharereportpermalink
u/sten_bhattacharya279 points·6 months ago

week 40 on Mounjaro and the appetite profile is genuinely different from sema

replysharereportpermalink
u/incretin_ivypharmacology345 points·6 months ago

Mechanistically the bit that matters is SURPASS. It explains most of the early profile and a decent chunk of the outcome.

replysharereportpermalink
u/mikkel_kimani-28 points·6 months ago

Small correction: the trial was 15 weeks, not 26. Does not change your point but people will quote it.

replysharereportpermalink
u/forest_plot_fionastats86 points·6 months ago

The confident tone is doing a lot of work that the evidence is not.

replysharereportpermalink

← back to the whole thread

About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

187kmembers
130submissions
Aug 2023created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
c/tirzepatide rules
  1. "Tirz is better than sema" needs a comparator dose or it is a vibe, not a claim.
  2. Vial-splitting and self-compounding discussion stays in c/reconstitution.
  3. No pen-cracking tutorials. Discussing that people do it is fine; instructions are not.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.