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c/tirzepatide·submitted 3 months ago by u/throwaway_titration

what changed for me between week 15 and week 58

Questionbranch of 7 comments

Confession thread, sort of. I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 2 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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7 comments, started 3 months ago
u/hub_opssite staff9 points·3 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/gentle_correctionnice about it6 points·3 months ago

Is that on Mounjaro pens or research tirzepatide?

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u/throwaway_titrationOP0 points·3 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/line_petrov1 point·3 months ago

the muscle cramps from tirz is different, not necessarily worse

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u/sofia_nascimento1 point·3 months ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/throwaway_titrationOP1 point·3 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/noor_hovland4 points·3 months ago·edited

the dual agonism hits different and that is why people describe it differently

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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