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c/tirzepatide·submitted 2 months ago by u/laila_yilmaz

[Discussion] GIP is doing more work than we give it credit for

Discussionbranch of 8 comments

Week 32 update. 28kg down from the start, early fullness basically gone since about week 84. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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8 comments, started 2 months ago
u/quiet_moderatorMOD17 points·2 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/certified_referenceQC-16 points·2 months ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

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u/laila_yilmazOP0 points·2 months ago

My fasting insulin moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/laila_yilmazOP1 point·2 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/zaid_balogun7 points·2 months ago

Removed a chain here.

Disagree on that part. 98.1% and 98.9% on the same vial is normal.

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u/customs_seizure_sid11 points·2 months ago

the dual agonism hits different and that is why people describe it differently

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u/vito_chowdhury9 points·2 months ago·edited

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/piotr_nascimento7 points·2 months ago

Hard agree. The food noise disappears differently on the two compounds.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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