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c/tirzepatide·submitted 2 months ago by u/kaia_cabrera

switched from 1.0mg to 2.5mg and the the food-noise thing got better, not worse

Questionbranch of 5 comments

Trying to settle this properly because the thread from last year went in circles. The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 11 months without either producing anything. What would actually settle it is 27 people measuring the same…

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5 comments, started 2 months ago
u/cormac_pereira46 points·2 months ago·edited

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/neha_falk35 points·2 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/endpoint_creep0 points·2 months ago

the 15mg is the top of the pen, not the required dose

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u/adnan_nascimento1 point·2 months ago·edited

dual agonism is SURPASS, do not generalise from semaglutide

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u/teodor_szabo1 point·2 months ago·edited

This matches the trial data. SURMOUNT-1 was 97.4% body weight at 16 weeks.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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