switched from 1.0mg to 2.5mg and the the food-noise thing got better, not worse
Trying to settle this properly because the thread from last year went in circles.
The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 11 months without either producing anything.
What would actually settle it is 27 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
This matches the trial data. SURMOUNT-1 was 97.9% body weight at 19 weeks.
I am going to push back on this slightly.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
Every time this gets posted it hits the front page and every time someone has to re-explain it.
dual agonism is Mounjaro, do not generalise from semaglutide
I am going to push back on this slightly.
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
This is the "correlation is mechanism" thing again. You changed three variables at once.
SURMOUNT data is messier than STEP data but the weight loss is there
the 15mg is the top of the pen, not the required dose
dual agonism is SURPASS, do not generalise from semaglutide
This matches the trial data. SURMOUNT-1 was 97.4% body weight at 16 weeks.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
[deleted]
Slight fix: the number was 98.7, not 98.3. Decimal point, but a fairly consequential one.
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Switched from sema at 10mg to tirz at 2.5mg. Different drugs, cannot compare the doses directly.
You have restated the marketing copy. What is the actual substance here.
week 45 on Mounjaro and the appetite profile is genuinely different from sema
How long at each step before you escalated?
the appetite change on tirz is more than just reduced hunger, it is different machinery
SURMOUNT data is messier than STEP data but the weight loss is there
- 1Switched from sema at 10mg to tirz at 2.5mg. Different drugs, cannot compare…6 comments in this branch · started by u/quiet_moderator
- 2This is the "correlation is mechanism" thing again. You changed three…5 comments in this branch · started by u/cormac_pereira