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c/tirzepatide·posted 5 months ago by u/hassan_nilsen

[Results] 56 weeks on 10mg, full numbers, ask me anything boring

Results Slow Clap ×7 Well Actually ×3 Long Haul ×2

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking tirzepatide against eGFR for 7 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

5,027 up / 403 down93% upvoted30 commentsid 1qz64z11 Feb 2026

30 comments

13 in this archive, depth 4

best — the order this archive was captured in

u/halima_boateng580 points·5 months ago

the dual agonism hits different and that is why people describe it differently

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u/sanne_novak467 points·5 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/halima_boateng683 points·5 months ago

the reflux from tirz is different, not necessarily worse

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u/hassan_nilsenOP0 points·5 months ago

do not crack the pen, we have been over this

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u/thyroid_tangent288 points·5 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/spain_receta301 points·5 months ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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[deleted]112 points·5 months ago

[deleted]

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u/emil_barros202 points·5 months ago

week 26 on Mounjaro and the appetite profile is genuinely different from sema

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u/sten_bhattacharya152 points·5 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/dexa_twice_yearlyMOD72 points·5 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/tove_vasquez114 points·5 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/bastian_ekstrom166 points·5 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

Yes, exactly this, and it is the bit that took me 74 weeks to accept.

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u/throwaway_titration55 points·5 months ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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