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c/tirzepatide·submitted 1 year ago by u/elin_varga

someone explain tirzepatide to me like I have not read a paper in years

Titrationbranch of 4 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking SURMOUNT against ApoB for 7 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one assay,…

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4 comments, started 1 year ago
u/aurel_lindqvist73 points·1 year ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/hugo_bergstrom51 points·1 year ago

Disagree. What you are describing is consistent with tirzepatide, not with what you concluded.

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u/gentle_correctionnice about it17 points·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/dario_stanescu21 points·1 year ago

the dual agonism hits different and that is why people describe it differently

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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