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c/tirzepatide·submitted 2 years ago by u/marta_dziedzic

[Vendor] QST order #6 — Denmark, 3 days, no drama, receipts inside

Side Effectsbranch of 13 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on Mounjaro in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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13 comments, started 2 years ago
u/ahmed_fonseca379 points·2 years ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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[removed]145 points·2 years ago

[removed by moderator]

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u/graph_it_gary73 points·2 years ago

[removed by moderator]

Adding to this: Mounjaro is doing more work than the comment implies.

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u/samir_falk57 points·2 years ago

Slight fix: the number was 98.3, not 98.4. Decimal point, but a fairly consequential one.

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u/ferritin_low262 points·2 years ago

How long at each step before you escalated?

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u/britt_okwuosa163 points·2 years ago

the the food-noise thing from tirz is different, not necessarily worse

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u/line_petrov73 points·2 years ago

Respectfully this is a sample of one presented as a finding.

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u/marta_dziedzicOP53 points·2 years ago

My ferritin moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/search_before_post124 points·2 years ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/sten_bhattacharya173 points·2 years ago·edited

the muscle cramps from tirz is different, not necessarily worse

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u/kofi_balogun55 points·2 years ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/laila_wikstrom313 points·2 years ago

Week 85 on Mounjaro and 13kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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u/marta_dziedzicOP123 points·2 years ago

Tried both. Sema worked, tirz worked better for me, but my early fullness profile was worse on tirz.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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