[Lab] 13th independent test on BCH, and the trend is the interesting part
Long-ish post, sorry. tl;dr at the bottom.
I have been tracking tirzepatide against eGFR for 21 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.
Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.
tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.
best — the order this archive was captured in
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Retitled to remove editorialising. Put the evidence in the body.
The dual agonism story is real. The appetite is physically different from semaglutide alone.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Switched from sema at 0.5mg to tirz at 1.0mg. Different drugs, cannot compare the doses directly.
the appetite change on tirz is more than just reduced hunger, it is different machinery
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
dual agonism is dual agonist, do not generalise from semaglutide
No.
Adding to this: Mounjaro is doing more work than the comment implies.
Strongly agree.
Adding to this: SURPASS is doing more work than the comment implies.
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
the dual agonism hits different and that is why people describe it differently
Every time this gets posted it hits the front page and every time someone has to re-explain it.
Hard agree. The food noise disappears differently on the two compounds.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
week 14 on Mounjaro and the appetite profile is genuinely different from sema
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
the dual agonism hits different and that is why people describe it differently
Hard agree.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
SURMOUNT data is messier than STEP data but the weight loss is there
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
the dual agonism hits different and that is why people describe it differently
Crossposting this to c/glp1uk because the people who need it are not reading this community.
Crossposting this to c/glp1uk because the people who need it are not reading this community.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
stalled on sema, tried tirz, and the curves were actually different shapes
Hard agree. The food noise disappears differently on the two compounds.
Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
- 1Every time this gets posted it hits the front page and every time someone…9 comments in this branch · started by u/ghrp_history
- 2Strongly agree. Tirz is better than sema is not a claim without a comparator…8 comments in this branch · started by u/certified_reference