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c/tirzepatide·posted 2 years ago by u/ingrid_correia

[Discussion] the tirzepatide advice in here is 22 years out of date

Discussion Slow Clap ×5 Sourced ×1

Been lurking in c/compounding for about 18 months and finally have something worth posting.

Short version: week 74, 2.5mg, and GIP is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 39 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 68.

3,423 up / 975 down78% upvoted29 commentsid 14ka588 Feb 2024

29 comments

11 in this archive, depth 3

best — the order this archive was captured in

u/nordic_pricing420 points·2 years ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/tidy_vialdrawer_pls345 points·2 years ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/ingrid_correiaOP208 points·2 years ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/adnan_nascimento132 points·2 years ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/dario_stanescu106 points·2 years ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/dexa_twice_yearlyMOD239 points·2 years ago

Tracking number removed. It identifies both ends of a shipment.

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u/ingrid_correiaOP133 points·2 years ago

Tracking number removed.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/sanne_novak152 points·2 years ago·edited

Hard agree. The food noise disappears differently on the two compounds.

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u/ferran_mensah107 points·2 years ago

SURMOUNT data is messier than STEP data but the weight loss is there

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[removed]49 points·2 years ago

[removed by moderator]

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u/vito_chowdhury77 points·2 years ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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