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c/survodutide·posted 2 years ago by u/cormac_danquah

19 months in and hepatic fat is still the thing I get wrong

Trial Data Slow Clap ×3

Been lurking in c/t2dglp1 for about 23 months and finally have something worth posting.

Short version: week 7, 1.7mg, and hepatic fat is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 29 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 96.

423 up / 12 down97% upvoted24 commentsid 1s7djc8 Apr 2024

24 comments

23 in this archive, depth 4

best — the order this archive was captured in

u/nora_oyelaran69 points·2 years ago

hepatic fat and survodutide are the story

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u/julia_mensa40 points·2 years ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/cold_chromatogram_only-28 points·2 years ago

the heart rate signal is real in the data

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u/cormac_danquah1 point·2 years ago

the heart rate signal is real in the data

Yes, exactly this, and it is the bit that took me 80 weeks to accept.

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u/nadia_bakker9 points·2 years ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/sofia_ferreira23 points·2 years ago

Strongly agree. The safety story is separate.

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u/liv_vukovic7 points·2 years ago·edited

Strongly agree.

Disagree on that part. 95.1% and 97.6% on the same vial is normal.

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u/hana_pereira20 points·2 years ago

Crossposting this to c/t2dglp1 because the people who need it are not reading this community.

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u/milan_mensah6 points·2 years ago

Yeah, glucagon co-agonism is genuinely different.

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u/incretin_ivypharmacology2 points·2 years ago

the safety profile is not just tirzepatide amplified

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u/customs_seizure_sid1 point·2 years ago

Strongly agree. The safety story is separate.

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u/customs_seizure_sid12 points·2 years ago
genuine question, not being difficult: how do you know
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u/trialwatch_theoMOD7 points·2 years ago

Tracking number removed. It identifies both ends of a shipment.

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u/elin_ferrari2 points·2 years ago·edited

Phase 14 or 6?

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u/milos_mensa4 points·2 years ago·edited

the GLP-1/glucagon dual is glucagon, different from GIP/GLP-1

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u/kaia_cabrera3 points·2 years ago

glucagon co-agonism has a different safety story

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u/quant_not_qual2 points·2 years ago

glucagon injection is a different vector than GLP-1

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u/cold_chromatogram_only1 point·2 years ago

glucagon co-agonism has a different safety story

Yes, exactly this, and it is the bit that took me 57 weeks to accept.

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u/joaquin_ivaturi9 points·2 years ago

Phase 19 or 32?

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u/jarno_adeyemi7 points·2 years ago·edited

This is correct. Do not generalise from tirzepatide.

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u/lyophile_lou2 points·2 years ago

the MASH indication changes the risk calculus

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u/yannick_petrov1 point·2 years ago

Yeah, glucagon co-agonism is genuinely different.

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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