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c/survodutide·submitted 2 years ago by u/cormac_danquah

19 months in and hepatic fat is still the thing I get wrong

Trial Databranch of 8 comments

Been lurking in c/t2dglp1 for about 23 months and finally have something worth posting. Short version: week 7, 1.7mg, and hepatic fat is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 29 threads, and the answers split roughly down the middle. What I actually want to know…

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8 comments, started 2 years ago
u/customs_seizure_sid12 points·2 years ago
genuine question, not being difficult: how do you know
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u/trialwatch_theoMOD7 points·2 years ago

Tracking number removed. It identifies both ends of a shipment.

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u/elin_ferrari2 points·2 years ago·edited

Phase 14 or 6?

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u/milos_mensa4 points·2 years ago·edited

the GLP-1/glucagon dual is glucagon, different from GIP/GLP-1

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u/kaia_cabrera3 points·2 years ago

glucagon co-agonism has a different safety story

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u/quant_not_qual2 points·2 years ago

glucagon injection is a different vector than GLP-1

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u/cold_chromatogram_only1 point·2 years ago

glucagon co-agonism has a different safety story

Yes, exactly this, and it is the bit that took me 57 weeks to accept.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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