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c/sideeffects·posted 3 months ago by u/isabela_nilsen

constipation is the most under-discussed thing in c/cryptopay

PSA Receipts ×2 Well Actually ×3

I have had 24 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 38 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 96.8% against a claimed 99.1%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

1,396 up / 344 down80% upvoted38 commentsid 19nszz2 Apr 2026

38 comments

27 in this archive, depth 4

best — the order this archive was captured in

u/mass_spec_maggieMS147 points·3 months ago

IANAD and neither is anyone upvoting this

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[removed]54 points·3 months ago

[removed by moderator]

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u/aa_analysis_andy103 points·3 months ago

Half-life is about 168 hours, so steady state lands around week 7–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/britt_abubakar66 points·3 months ago

The muscle cramps was genuinely awful for three weeks and then simply stopped. Week 20 me did not think I would make it to week 72.

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u/zeynep_ndiaye23 points·3 months ago

resting heart rate moved up 24 bpm and settled back down when I stopped escalating

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u/usp_appendixcompendial17 points·3 months ago·edited

resting heart rate moved up 8 bpm and settled back down when I stopped escalating

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u/salma_baptista20 points·3 months ago

IANAD and neither is anyone upvoting this

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u/janoshik_junkieindependent tester44 points·3 months ago

My sulphur burps was worst at 1.7mg and better at 1.7mg, which makes no sense but it is real.

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u/insulin_syringe_ian34 points·3 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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u/isabela_nilsenOP24 points·3 months ago

Resting heart rate up 22 bpm from baseline, settled back down once I stopped escalating. Tracked daily so I am confident.

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u/marta_marchand16 points·3 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/neha_rahimi19 points·3 months ago

This is correct. The reflux is horrible for three weeks and then just ends.

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u/quiet_moderatorMOD31 points·3 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/isabela_nilsenOP23 points·3 months ago

Went to A&E convinced it was pancreatitis. Lipase normal. It was gallstones. Get checked, do not post and wait.

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u/food_noise_gonemaintenance16 points·3 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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u/lina_dziedzic-26 points·3 months ago

resting heart rate moved up 19 bpm and settled back down when I stopped escalating

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u/isabela_nilsenOP1 point·3 months ago

resting heart rate moved up 19 bpm and settled back down when I stopped escalating

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/marit_coelho1 point·3 months ago

week 46 and the the food-noise thing is finally getting better

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u/elin_lindqvist1 point·3 months ago

I am going to push back on this slightly.

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u/sanne_laurent1 point·3 months ago

ask your actual doctor, not us

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u/saskia_lokken21 points·3 months ago

resting heart rate moved up 12 bpm and settled back down when I stopped escalating

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u/clara_weiss17 points·3 months ago

constipation is real, boring, and fixable

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u/iman_castellanos8 points·3 months ago

This is correct. The nausea is horrible for three weeks and then just ends.

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u/placebo_arm_pam4 points·3 months ago

the food-noise thing stops around week 96 for most people

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u/adnan_karlsen11 points·3 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/nausea_notesside effects6 points·3 months ago

This is correct. The sulphur burps is horrible for three weeks and then just ends.

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u/quiet_moderatormod2 points·3 months ago

This is correct.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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c/sideeffects rules
  1. Severe or escalating abdominal pain is an urgent-care question, not a forum question. We will lock those threads with a pointer to help.
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