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c/semaglutide·submitted 7 months ago by u/hamza_weiss

the semaglutide question that gets asked weekly, answered properly

Side Effectsbranch of 6 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking 2.4mg against ApoB for 5 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one assay, no…

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6 comments, started 7 months ago
u/alcohol_aversion186 points·7 months ago

Half-life is about 168 hours, so steady state lands around week 7–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/elodie_grimaldi124 points·7 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/hamza_weissOP79 points·7 months ago

The confident tone is doing a lot of work that the evidence is not.

Adding to this: weekly dosing is doing more work than the comment implies.

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[removed]54 points·7 months ago

[removed by moderator]

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u/two_mil_or_one0 points·7 months ago

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/rina_bergstrom53 points·7 months ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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